In 2006, friends Mary Fuchs, Alice Campbell & Kathy May realized there was an absence of chronic medical care for the working poor in the Brazosport area. Dr. Sanjay Aggarwal agreed to become the volunteer medical director.
In 2007, Live Oak Clinic opened inside the Brazoria County Dream Center.
In 2014, Live Oak Clinic was invited to relocate to remodeled space inside Covenant Evangelical Presbyterian Church.
In 2017, Dr. Raj Mikkilineni closed her Angleton charity clinic and merged with Live Oak Clinic.
In 2018, Live Oak Clinic celebrated 11 years of successful operation treating over 1,000 patient and offering volunteer opportunities to medical practitioners and others with valued skills.